70 Ti fixed-angle rotor: performance and reliability for intensive ultracentrifugation
The Beckman Coulter 70 Ti rotor is an iconic fixed-angle rotor model, renowned for its exceptional performance in ultracentrifugation. Designed specifically for the brand's H, R and S class preparative ultracentrifuges, this rotor embodies the precision and safety required for sensitive biomolecule separations or applications requiring complex gradients. Its name, "70 Ti", refers to its maximum rotation speed of 70,000 RPM and its main material: titanium, chosen for its light weight, mechanical strength and chemical compatibility.
The rotor has eight cavities that can accommodate different types of tubes, including Quick-Seal, OptiSeal, and thin- and thick-walled tubes. Each cavity is inclined at a fixed angle of 23°, ensuring efficient particle sedimentation. At full capacity, the rotor can process up to 312 mL of sample, making it particularly suitable for demanding protocols for the purification of viruses, cell organelles or protein aggregates.
The rotor design incorporates essential safety features. An overspeed detection disc, located at its base, is monitored by the centrifuge, which automatically stops the cycle if the speed exceeds 70,000 RPM, protecting both the user and the equipment. Buna N O-rings ensure optimal sealing, while the anodised aluminium lid is specially profiled to improve the centrifugal closing force. Four ventilation holes prevent internal overpressure in the event of accidental leakage, further enhancing safety during use.
The 70 Ti is a rotor designed to last. It is protected against corrosion by black polyurethane paint and requires regular, simple maintenance to ensure its longevity.
One of the great advantages of the 70 Ti is its versatility. It is compatible with a wide range of tubes, materials (polypropylene, polycarbonate, stainless steel, etc.) and formats ranging from 4 to 39 mL. These tubes can be used with standard or specific caps, such as titanium crimp-lock caps, ensuring their integrity even at full speed. Some tubes also require the use of spacer rings to ensure perfect symmetrical positioning in the rotor, which is essential to prevent imbalances.
The rotor fits perfectly into biosafety protocols. It can be cleaned, disinfected and even sterilised in an autoclave (121°C for one hour) without risk to its components, with the exception of certain plastic parts. Chemical decontamination procedures are also available for applications requiring a high level of sterility.
The 70 Ti is the benchmark choice for researchers and laboratories requiring precision, safety and maximum compatibility with modern ultracentrifugation methods.
