APAG: Heating Device for Plasma Albumin for Aesthetic Use
The APAG (Activated Plasma Albumin Gel) system developed by Silfradent meets specific needs in the field of regenerative aesthetic medicine. This electrical medical device is designed to heat syringes containing platelet-poor plasma (PPP) to a controlled temperature. The process is based on the thermal aggregation of human serum albumin (HSA), resulting in the formation of a biocompatible polymer with a fibrillar structure, which can be used as a filler material in aesthetic procedures.
This temperature- and time-induced aggregation phenomenon transforms plasma proteins into elongated oligomers with mechanical properties useful for injection. During this process, the secondary and tertiary structure of the protein is altered while the peptide bonds of the primary structure are preserved, thus ensuring morphological stability without the risk of undesirable reactivity.
APAG therefore enables the production of a stable gel that is sterile and preservative-free gel that can be used for a variety of applications such as facial volumisation, cell regeneration, wrinkle and fine line reduction, acne scar treatment, skin texture improvement, and revitalisation of the neck, décolleté, hands and areas affected by alopecia.
Compact and easy to integrate into a medical practice, APAG is simple to use thanks to its ergonomic design and precise heating settings. It is part of an autologous treatment approach, significantly reducing the risk of rejection or allergic reactions.
The device complies with European medical safety and hygiene standards, while allowing optimal reproducibility of results for professionals wishing to introduce or improve aesthetic procedures based on the patient's own blood components.
This autologous protocol, based entirely on the patient's own plasma, is part of a personalised aesthetic approach that respects individual biological balance.
