ProStar 410 HPLC Autosampler – Performance and Precision for Your Analytical Workflow
The ProStar 410 HPLC autosampler from Varian is a high-performance module designed to automate the injection of samples into liquid chromatography systems with precision, reliability, and consistency. It is aimed at laboratories seeking to optimize productivity without compromising analytical quality. With its robust mechanics, modular design, and compatibility with Varian's control software, this instrument integrates seamlessly into a complete HPLC chain. It allows for the planning, execution, and chaining of injection sequences with high accuracy, while ensuring efficient performance monitoring and maintenance. The ProStar 410 is a strategic choice for research, quality control, or production environments that require automation, consistency, and adaptability to a wide variety of methods.
This system uses a high-resolution motorized syringe to perform injections with exceptional accuracy through three main modes: full-loop, partial-loop, and μL Pick-up. This flexibility allows the user to tailor the injection process to the sample type or method requirements, minimizing waste and ensuring excellent reproducibility. The injected volume is finely and consistently controlled, which reduces analytical variability and guarantees reliable results. Users can also program reagent additions, derivatization steps, or rinse sequences between injections—features that are essential for complex or contamination-sensitive methods. All these operations are fully automated, contributing to the rigor of the analysis while freeing up valuable operator time.
As temperature is a critical factor in chromatography, the ProStar 410 includes a built-in column thermostat to ensure consistent retention and separation. An optional thermoelectric cooling module allows for sample vial cooling to temperatures below ambient, down to 4 °C. This thermal control is essential for the stability of sensitive compounds and helps avoid sample degradation prior to injection, especially in labs with fluctuating ambient conditions. The precise regulation of both sample and column temperatures ensures optimal preservation throughout the analytical sequence. This feature makes the ProStar 410 an ideal solution in pharmaceutical, environmental, clinical, and food testing applications where traceability and analytical rigor are essential.
The instrument has been designed with user-friendliness in mind, making it intuitive and accessible for operators of all levels. Its user interface allows for easy navigation and quick setup of injection sequences. When used in conjunction with the Varian Star Workstation software, it supports full remote control, data tracking, and integration into laboratory information management systems. Maintenance is quick and simple: the injection valve can be replaced in seconds without tools. Built-in alerts notify the user of excessive valve torque or worn seals, allowing for efficient preventive maintenance. The internal structure has been optimized to reduce downtime, extend the instrument’s lifespan, and simplify cleaning and upkeep.
Lastly, the ProStar 410 stands out for its rugged construction and compliance with international quality standards. It was developed to meet Good Laboratory Practice (GLP) guidelines and the expectations of ISO-certified laboratories. Its compact, stackable design allows for easy integration with other Varian HPLC modules, even in space-constrained setups. Moreover, it is compatible with a wide range of accessories, sample vials, syringes, and loops, enabling customization based on the specific needs of each laboratory. Its modular and scalable design makes it a smart and sustainable choice for modern HPLC installations looking for long-term performance and peace of mind.
