RF3000® – The precision radiofrequency generator for controlled thermal ablation of soft tissue
The RF3000® from Boston Scientific is a highly specialised radiofrequency generator for thermal ablation of soft tissue, particularly in the treatment of unresectable liver lesions. When used with the LeVeen® electrode , it represents a major advance in radiofrequency treatment thanks to its unique ability to monitor tissue impedance changes in real time, a key factor in the safety and accuracy of the procedure.
Radiofrequency ablation is based on the use of high-frequency alternating current (between 400,000 and 1,250,000 Hz) emitted from a non-insulated electrode tip to the targeted tissue. This current causes ionic agitation, which generates frictional heating in the tissue, leading to cell destruction via protein denaturation and intracellular dehydration. These phenomena increase tissue impedance, a measurable resistance that becomes a reliable indicator of the progress and completion of ablation.
The RF3000® is designed to operate in "constant voltage" mode, delivering up to 200 W of energy. It begins applying energy by measuring the initial impedance of the tissue, often between 40 and 80 ohms. As the thermal lesion progresses, the tissue around the electrode dries out, the impedance increases, and the current is redirected to the still viable areas, creating a homogeneous and progressive ablation sphere. The generator tracks this progression by illuminating a front bar graph, which, when fully activated, indicates completion of the lesion and a power drop below 10 W.
This impedance-based feedback is a valuable clinical indicator, preventing over-ablation or under-treatment. The system can self-adjust by reducing power when tissue resistance becomes too high, thus preventing unnecessary damage to surrounding tissue. This automated process makes procedures safer and more reproducible, while reducing dependence on individual operator experience.
The RF3000® is not MRI compatible, an important precaution for advanced imaging environments. Boston Scientific recommends the use of four Valleylab® Polyhesive® return electrodes, two per leg, for optimal current dispersion. In addition, the generator interface is designed to facilitate voltage adjustment and monitor ablation status visually and intuitively, ensuring effective handling for clinicians.
It is important to note that although this device is designed for the ablation of liver lesions, its clinical effectiveness in the treatment of cancer or other liver diseases has not been officially established. Its use is restricted to trained and qualified healthcare professionals, and the device is subject to US legislation restricting its sale to prescription only.
