PhysioMimix OOC Multi-Organ Microphysiological System: Enhancing Drug Discovery with Human-Relevant Insights
The PhysioMimix OOC Multi-Organ Microphysiological System from CN Bio is a cutting-edge organ-on-a-chip platform designed to improve the accuracy of preclinical drug testing by replicating human physiological conditions in vitro. By enabling the culture of microtissues that closely mimic human organs, PhysioMimix allows researchers to generate predictive, translational data for drug discovery, disease modeling, and toxicology studies. This system bridges the gap between traditional in vitro assays and human clinical trials, reducing reliance on animal models while increasing the reliability of experimental outcomes.
PhysioMimix supports both single-organ and multi-organ models, allowing researchers to study individual organ responses or complex inter-organ interactions. The multi-organ configuration enables the analysis of crosstalk between tissues, providing insights into systemic drug effects, metabolism, and disease progression. The perfused system accurately replicates fluidic flow dynamics within the human body, maintaining tissue viability over extended periods. It also facilitates the inclusion of circulating immune cells, making it suitable for immuno-oncology, inflammation, and infectious disease research.
The platform’s open-well plate format simplifies experiment setup and sample collection while allowing for high-content imaging, biomarker analysis, and multi-omics studies. Researchers can perform both acute and chronic exposure experiments, recovering media samples for real-time monitoring and longitudinal analysis. With its ability to support larger-scale tissue and media volumes, PhysioMimix is optimized for high-throughput screening, increasing efficiency and reducing overall costs.
PhysioMimix is designed for seamless integration into existing laboratory workflows. Its compact, benchtop-compatible design fits within standard incubators, and the automated perfusion system minimizes manual intervention, ensuring reproducibility across experiments. The user-friendly interface allows researchers to quickly set up and execute experiments with minimal training, making it accessible for a wide range of applications. The system supports various pre-formed tissues and cell types, offering flexibility for different research needs.
The PhysioMimix platform plays a crucial role in pharmaceutical research by enhancing the understanding of drug efficacy, toxicity, and metabolism. It is widely used in safety pharmacology, ADME studies, and personalized medicine, providing researchers with robust human-relevant data that improves the predictability of clinical outcomes. By reducing experimental costs and time while increasing data confidence, PhysioMimix helps streamline drug development, accelerating the path from discovery to clinical application.
