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nCounter Gene Analysis System - Good Condition

Bruker's nCounter® analysis system revolutionises gene expression quantification with its direct digital counting technology. Offering robust performance, broad compatibility with various sample types and efficient automation, it delivers reproducible results without complex enzymatic steps. Designed for research, nCounter® accelerates biomarker discovery and development by combining test flexibility, workflow simplicity and powerful bioinformatics analysis. It is the ideal solution for accurate, high-throughput molecular biology analysis.



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Description

nCounter® Analysis System: a system for gene analysis

Bruker's nCounter® Analysis System is a state-of-the-art platform dedicated to gene expression analysis, which has become a benchmark in biomedical and pharmaceutical research laboratories. Thanks to its direct digital detection technology, this system enables the accurate counting of thousands of target molecules without the need for enzymatic steps such as reverse transcription or amplification, ensuring unrivalled technical reproducibility and optimal accuracy.

One of the key strengths of nCounter® is its ability to process a wide range of samples, including those considered difficult, such as old FFPE tissues, blood and biofluids. This gives researchers considerable flexibility in their choice of samples and facilitates longitudinal studies with high confidence in data quality.

The nCounter® also stands out for its efficient, automated workflow. With human intervention reduced to less than 15 minutes for most tests and a turnaround time of less than 24 hours, it allows research teams to optimise their productivity and spend more time on scientific analysis. The ability to process up to 96 samples per run using PlexSet™ chemistry makes it a highly scalable solution suitable for both small validation projects and high-throughput screening studies.

In terms of performance, the platform offers a linear dynamic range over five orders of magnitude and remarkable sensitivity, capable of detecting expression differences even in degraded samples. The unique probe design, requiring only a 100 base pair region for hybridisation, contributes to the robustness of the results.

To support researchers in exploiting their data, Bruker offers powerful and intuitive analysis tools, such as nSolver™ software and the ROSALIND® cloud platform, enabling rapid visualisation of experimental trends and in-depth interpretation of results without the need for bioinformatics expertise.

The nCounter® Analysis System is part of a continuous innovation process, offering laboratories a reliable, flexible and high-performance tool to accelerate the discovery and development of biomarkers.


Features

  • Direct digital counting without enzymatic steps
  • Compatibility with complex and degraded samples (FFPE, sera, cell lysates)
  • Automated workflow with reduced human intervention
  • Screening of 12 to 576 samples per day (depending on configuration)
  • Simplified bioinformatics support with tools such as nSolver™ and ROSALIND®
  • Over 7,000 publications validating the technology in various research fields
  • Ability to generate high-quality data for validation and discovery projects
  • Integration possible with other Bruker spatial technologies for multi-scale analysis

Technical Details

  • Multiplexing: up to 800 targets simultaneously
  • Recommended starting material:
    • RNA: 1-100 ng
    • DNA: 5-300 ng
  • Supported sample types: Total RNA, cell lysates, RNA extracted from FFPE, total blood lysed with PAXgene
  • Reaction volume: up to 30 µL
  • Detection limit: 15 zeptomoles in 15 µL of hybridisation
  • Linear regression correlation: R² > 0.95
  • Linear dynamic range: 6 x 10⁵ total counts
  • Handling time: approximately 15 minutes
  • Processing time: up to 576 samples/day with multiple preparation stations
  • Dimensions:
    • Preparation station: 67 x 89 x 63 cm
    • Digital analyser: 66 x 66 x 48 cm
  • Weight:
    • Preparation station: 120 kg
    • Digital analyser: 67 kg


Compatible Accessories

  • Additional preparation station to increase throughput
  • PlexSet™ reagents for advanced multiplexing
  • Hybridisation kits for different sample types (RNA, DNA, FFPE)
  • Analysis software: nSolver™ and ROSALIND®
  • Panel Plus™ extension modules for panel customisation
  • Heating blocks for overnight hybridisation
  • Analysis cartridges suitable for different sample volumes

Logistics

Remma and its partners provide you with serviced and configured equipment tailored to your needs. Receive your product at your facility with standard or express delivery, and an installation option, all through a single point of contact.

Warranty

Our 12/24-month warranty ensures the safety and reliability of your medical equipment throughout its lifespan.

Flexible Financing

Settle your medical equipment in up to 36 installments with our financing service or pay after delivery with Remma Facility.