TSQ Quantiva from Thermo Fisher Scientific: Triple quadrupole mass spectrometer for exceptional quantitative performance
The TSQ Quantiva triple quadrupole mass spectrometer from Thermo Fisher Scientific has been designed to meet the most rigorous analytical requirements. Thanks to Active Ion Management (AIM) technology, it offers unrivalled detection and quantification limits, enabling the quantification of complex and difficult-to-analyse samples with exceptional accuracy. This ability to detect and quantify ultra-low levels of compounds does not compromise the instrument's ease of use or reliability, which features innovative hardware and software design for easy everyday operation.
The TSQ Quantiva's hardware architecture incorporates the Ion Max NG API source, which simplifies automatic gas and voltage connection, improving reliability and reducing manual intervention. This source is equipped with an optimised 60-degree spray angle and allows the interchangeable use of HESI and APCI ionisation probes. High-capacity transfer tube technology improves sensitivity by introducing more ions into the vacuum system while ensuring efficient desolvation. The electrodynamic ion funnel captures ions efficiently, reducing losses and limiting fragmentation at the source.
HyperQuad mass filters (Q1 and Q3) offer high ion transmission and increased sensitivity thanks to a specific radiofrequency field design, enabling resolution up to 0.2 FWHM. The active collision cell, filled with argon, ensures efficient fragmentation with a capacity of up to 500 SRM transitions per second without cross-interference. The dual-mode discrete dynode detector (pulse counting and analogue) ensures a wide dynamic range over six orders of magnitude, for reliable quantification even at variable ion flows.
The software aspect of the TSQ Quantiva complements its hardware capabilities with an intuitive interface. The Xcalibur software offers full instrument control and optimised data acquisition, while the TraceFinder and LCQUAN modules simplify method development and routine analysis. Compatibility with tools such as Mass Frontier and Skyline also enables specialised applications in clinical research, food safety and toxicology.
By combining sensitivity, speed and simplicity, the TSQ Quantiva allows researchers to focus on their analyses without being hampered by operational complexity, ensuring maximum productivity in a variety of laboratory environments.
